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KW-2449

CAS No. 1000669-72-6

KW-2449 ( KW 2449;KW2449 )

Catalog No. M10007 CAS No. 1000669-72-6

A multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KW-2449
  • Note
    Research use only, not for human use.
  • Brief Description
    A multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.
  • Description
    A multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively; has little effect on PDGFRβ, IGF-1R, EGFR, and various serine/threonine kinases at 1 uM; exhibits potent growth inhibitory effects on leukemia cells with FLT3 mutations, resulting in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis; orally active.Blood Cancer Discontinued
  • Synonyms
    KW 2449;KW2449
  • Pathway
    Tyrosine Kinase
  • Target
    FLT3
  • Recptor
    Abl;Abl(T315I);AuroraA;FGFR1;FLT3;FLT3(D835Y);JAK2;Kit;Src
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1000669-72-6
  • Formula Weight
    332.40
  • Molecular Formula
    C20H20N4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CC=C(/C=C/C2=NNC3=C2C=CC=C3)C=C1)N4CCNCC4
  • Chemical Name
    Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shiotsu Y, et al. Blood. 2009 Aug 20;114(8):1607-17.
2. Nguyen T, et al. Clin Cancer Res. 2011 May 15;17(10):3219-32.
3. Pratz KW, et al. Blood. 2009 Apr 23;113(17):3938-46.
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