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KIN-1408

CAS No. 1903800-11-2

KIN-1408( KIN-1408 | KIN 1408 )

Catalog No. M12985 CAS No. 1903800-11-2

A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KIN-1408
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae.
  • Description
    A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus); induces relocalization of pTBK1 from centrosomes to mitochondria, and increases CASP3-mediated cell death; the RIG-I-like receptor (RLR) agonist.
  • In Vitro
    KIN1408 has the potency to drive IRF3 activation to induce innate immune gene (MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells) expression and that concomitantly suppress dengue virus2 RNA to levels. KIN1408 also exhibits activity against HCV, influenza A, Ebola, Nipah, and Lassa viruses.
  • In Vivo
    ——
  • Synonyms
    KIN-1408 | KIN 1408
  • Pathway
    Immunology/Inflammation
  • Target
    RLR
  • Recptor
    RLR
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    1903800-11-2
  • Formula Weight
    479.4985
  • Molecular Formula
    C25H19F2N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 39 mg/mL
  • SMILES
    OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(OC(F)F)C=C3)NC4=NC5=CC(OC)=CC=C5S4
  • Chemical Name
    7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Green RR, et al. Genom Data. 2016 Feb 1;7:290-2. 2. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87. 3. Onorati M, et al. Cell Rep. 2016 Sep 6;16(10):2576-92.
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