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Home - Products - Chromatin/Epigenetic - Histone Demethylase - KDM-IN-6

KDM-IN-6

CAS No. 2169272-46-0

KDM-IN-6( —— )

Catalog No. M13462 CAS No. 2169272-46-0

KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KDM-IN-6
  • Note
    Research use only, not for human use.
  • Brief Description
    KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively.
  • Description
    KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively; displays >75 fold selectivity towards KDM2A/7A versus other JmjC lysine demethylase; shows cytotoxicity towards HeLa and HAP1 cells with EC50 of 22 uM and 7.1 uM respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2169272-46-0
  • Formula Weight
    506.694
  • Molecular Formula
    C33H38N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (394.73 mM)
  • SMILES
    CC(N([C@@H](C1=CN=CC(CCCCCCCN2CCCC2)=C1)[C@@]3(C4=CC=CC=C4)C#N)C5=C3C=CC=C5)=O
  • Chemical Name
    (2S,3S)-1-acetyl-3-phenyl-2-(5-(7-(pyrrolidin-1-yl)heptyl)pyridin-3-yl)indoline-3-carbonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gerken P, et al. Angew Chem Int Ed Engl. 2017 Oct 4. doi: 10.1002/anie.201706788.
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