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JQKD82
CAS No. 2410512-38-6
JQKD82 ( JADA82; PCK82 )
Catalog No. M28249 CAS No. 2410512-38-6
JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 555 | Get Quote |
|
| 10MG | 896 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameJQKD82
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NoteResearch use only, not for human use.
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Brief DescriptionJQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.
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DescriptionJQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.(In Vitro):In MM.1S and MOLP-8 cells, JQKD82 (1 μM) induces G1 cell cycle arrest. JQKD82 (0.3 μM) increases global H3K4me3 levels in MM.1S cells. JQKD82 (0.1-10 μM) inhibits the growth of MM.1S cells in a dose- and time-dependent manner (IC50 = 0.42 μM).(In Vivo):In female NSG mice bearing MOLP-8 TurboGFP-Luc cells, JQKD82 (50 and 75 mg/kg; i.p.) significantly reduces tumor burden. JQKD82 increases the level of H3K4me3 and significantly reduces MYC immuno-staining in vivo.
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SynonymsJADA82; PCK82
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorL. donovani
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Research Area——
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Indication——
Chemical Information
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CAS Number2410512-38-6
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Formula Weight500.6
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Molecular FormulaC27H40N4O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OC1=CC=C(OC(C)C)C=C1OC(C)C)C=2C=CN=C(C2)CNCC(=O)N(CC)CCN(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wyllie S, et al. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Nature. 2018 Aug;560(7717):192-197.
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