Cart
sales@molnova.com
T-3775440
CAS No. 1422620-34-5
T-3775440 ( T 3775440;T3775440 )
Catalog No. M11775 CAS No. 1422620-34-5
T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameT-3775440
-
NoteResearch use only, not for human use.
-
Brief DescriptionT-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
-
DescriptionT-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models.
-
SynonymsT 3775440;T3775440
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorHistone Demethylase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1422620-34-5
-
Formula Weight310.40
-
Molecular FormulaC18H22N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCN1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4
-
Chemical NameN-(4-((1S,2R)-2-((cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016.
2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284.
2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284.
molnova catalog
related products
-
LSD1-IN-7 benzenesul...
LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.
-
L-α-Hydroxyglutaric ...
L-α-Hydroxyglutaric acid disodium salt (L-2-Hydroxyglutarate;L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases.
-
D-alpha-Hydroxygluta...
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
