
JSH-23
CAS No. 749886-87-1
JSH-23( NF-κB Activation Inhibitor II )
Catalog No. M15858 CAS No. 749886-87-1
JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.
Purity : >98% (HPLC)






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Biological Information
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Product NameJSH-23
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NoteResearch use only, not for human use.
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Brief DescriptionJSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.
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DescriptionJSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.(In Vitro):JSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells.Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner.(In Vivo):JSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats.
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In VitroJSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells.Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner.Cell Cytotoxicity Assay Cell Line:Macrophages RAW 264.7 Concentration:1, 3, 10, 30, 100, 300 μM Incubation Time:24 hours Result:Did not show significant cytotoxic effects at <100 μM.Western Blot Analysis Cell Line:Macrophages RAW 264.7 with LPS-stimulated Concentration:30 μM Incubation Time:1 hour Result:Decreased nuclear content of NF-κB p65 in a dose-dependent manner, corresponding to 49±4% inhibition at 3 μM, 75±7% at 10 μM and 95±8% at 30 μM.
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In VivoJSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats. Animal Model:Male Sprague Dawley diabetic rats (250-270 g)Dosage:1 mg/kg, 3 mg/kg Administration:Orally administered; daily; for 2 weeks Result:Produced significant improvement in motor nerve conduction velocity (MNCV).
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SynonymsNF-κB Activation Inhibitor II
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number749886-87-1
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Formula Weight240.34
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Molecular FormulaC16H20N2
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Purity>98% (HPLC)
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SolubilityEthanol: 20 mg/mL (83.21 mM); DMSO: 48 mg/mL (199.71 mM)
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SMILESNC1=CC(C)=CC=C1NCCCC2=CC=CC=C2
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Chemical Name4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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