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Home - Products - GPCR/G Protein - Cholecystokinin Receptor - JNJ-26070109

JNJ-26070109

CAS No. 844645-08-5

JNJ-26070109( JNJ 26070109 | JNJ26070109 )

Catalog No. M16137 CAS No. 844645-08-5

A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JNJ-26070109
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.
  • Description
    A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ 26070109 | JNJ26070109
  • Pathway
    GPCR/G Protein
  • Target
    Cholecystokinin Receptor
  • Recptor
    Cholecystokinin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    844645-08-5
  • Formula Weight
    547.37
  • Molecular Formula
    C23H17BrF2N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N[C@@H](C1=CC=C(F)C=C1F)C)C2=CC=C(Br)C=C2NS(=O)(C3=C4N=CC=NC4=CC=C3)=O
  • Chemical Name
    (R)-4-Bromo-N-[1-(2,4-difluorophenyl)ethyl]-2-[[(quinoxalin-5-yl)sulfonyl]amino]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. 2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93.
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