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JNJ-1A

CAS No. ——

JNJ-1A( —— )

Catalog No. M17087 CAS No. ——

JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JNJ-1A
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM.
  • Description
    JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM, in the absence of cytotoxicity; shows equipotent antiviral activity against DENV serotypes 1, 2, and 4, induces mutation T108I in non-structural protein 4B (NS4B) in in vitro resistance selection experiments.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Filovirus
  • Recptor
    Filovirus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    761.942
  • Molecular Formula
    C42H47N7O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    methyl ((S)-1-((S)-2-(5-(7-(2-((S)-1-(benzylsulfonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-9,10-dihydrophenanthren-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hernandez-Morales I, et al. Antiviral Res. 2017 Nov;147:149-158.
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