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JNJ-1A
CAS No. ——
JNJ-1A( —— )
Catalog No. M17087 CAS No. ——
JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJNJ-1A
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM.
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DescriptionJNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM, in the absence of cytotoxicity; shows equipotent antiviral activity against DENV serotypes 1, 2, and 4, induces mutation T108I in non-structural protein 4B (NS4B) in in vitro resistance selection experiments.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetFilovirus
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RecptorFilovirus
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight761.942
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Molecular FormulaC42H47N7O5S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Namemethyl ((S)-1-((S)-2-(5-(7-(2-((S)-1-(benzylsulfonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-9,10-dihydrophenanthren-2-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hernandez-Morales I, et al. Antiviral Res. 2017 Nov;147:149-158.
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