IHVR-19029

Research use only, not for human use.

IHVR-19029 is a novel antiviral compound that acts as ER α-glucosidase inhibitor.

IHVR-19029 is a novel antiviral compound that acts as ER α-glucosidase inhibitor, synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells combined with favipiravir (T-705); significantly increases the survival rate of infected animals in mouse model of Ebola virus infection.

IHVR-19029 efficiently inhibits Bovine viral diarrhea virus (BVDV), Tacaribe virus (TCRV) and Dengue virus (DENV) with EC50s of 0.25, 0.74, and 1.25 μM, respectively.The combination of IHVR-19029 and Favipiravir (HY-14768) synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells.

IHVR-19029 (25-75 mg/kg; I.p.; twice daily for 10 days) inhibits EBOV and MARV infection in mice.IHVR-19029 (5 mg/kg; i.v.) has AUC, C0, T1/2, CL and Vd values of 1383 μg*h/mL, 1.79 μg/mL, 1.2 hours, 3.49 L/h/kg, and 3.0 L/kg, respectively. IHVR-19029 (75/5/5 mg/kg; p.o./i.m./i.p.) has AUC values of 945/1839/983 μg*h/mL, Cmax values of 0.26/1.23/1.33 μg/ml, Tmax values of 2.1/0.1/0.17 hours, and F values of 4.6/71/133%, respectively. Animal Model:BALB/c mice (12 week 233 of age) (MARV infection) Dosage:25, 75 mg/kg Administration:I.p.; twice daily, until 10 days Result:Significant protection of Marburg virus (MARV) induced death were observed.Animal Model:C57B1/6 mice (8–12 week of age) (EBOV infection)Dosage:25, 75 mg/kgAdministration:I.p.; twice daily for 10 daysResult:Significant survival were observed.

IHVR19029

Microbiology/Virology

Filovirus

Filovirus

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1447464-73-4

443.629

C23H45N3O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (225.42 mM)

O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCN(C(NC(C)(C)C)=O)C2CCCCC2)C[C@@H]1O

3-(tert-butyl)-1-cyclohexyl-1-(6-((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)hexyl)urea

(-20℃)

With Ice Pack

≥ 2 years