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JNJ-1289
CAS No. 792898-18-1
JNJ-1289( —— )
Catalog No. M35465 CAS No. 792898-18-1
JNJ-1289 is a selective, potent, and competitive inhibitor of human spermine oxidase (hSMOX) with an IC50 value of 50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 301 | Get Quote |
|
| 5MG | 491 | Get Quote |
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| 10MG | 692 | Get Quote |
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| 25MG | 1132 | Get Quote |
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| 50MG | 1500 | Get Quote |
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| 100MG | 1971 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJNJ-1289
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-1289 is a selective, potent, and competitive inhibitor of human spermine oxidase (hSMOX) with an IC50 value of 50 nM.
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DescriptionJNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers.
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In VitroJNJ-1289 (0 and 2 h) inhibits hSMOX activity in a time-dependent manner.JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex.
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetSmoothened (Smo)
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RecptorSmo
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Research Area——
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Indication——
Chemical Information
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CAS Number792898-18-1
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Formula Weight308.36
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Molecular FormulaC16H12N4OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (324.30 mM; Ultrasonic )
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SMILESN(C1=NC(C=2N3C(=NC2)C=CC=C3)=CS1)C4=CC=C(O)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787. ?
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