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JG-231
CAS No. 1627126-59-3
JG-231( JG231 )
Catalog No. M12408 CAS No. 1627126-59-3
JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 282 | Get Quote |
|
| 10MG | 462 | Get Quote |
|
| 25MG | 763 | Get Quote |
|
| 50MG | 1053 | Get Quote |
|
| 100MG | 1422 | Get Quote |
|
| 500MG | 2853 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJG-231
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NoteResearch use only, not for human use.
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Brief DescriptionJG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM).
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DescriptionJG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip).
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In Vitro——
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In Vivo——
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SynonymsJG231
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1627126-59-3
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Formula Weight619.45
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Molecular FormulaC22H18BrCl2N3OS4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 2 mg/mL (3.23 mM)
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SMILESO=C1N(CC)/C(S/C1=C2SC3=CC(Cl)=CC=C3N/2C)=C/C4=[N+](CC5=CC=C(Br)S5)C=CS4.[Cl-]
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Chemical Name3-((5-bromothiophen-2-yl)methyl)-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583.
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