Isochamaejasmine

Research use only, not for human use.

Isochamaejasmine is a biflavonoid isolated from S. chamaejasme L. with inhibition of NF-κB activation. Isochamaejasmine induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins and can be used in anti-cancer studies.

Isochamaejasmine is a biflavonoid isolated from S. chamaejasme L. with inhibition of NF-κB activation. Isochamaejasmine induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins and can be used in anti-cancer studies.(In Vitro):Isochamaejasmine shows antiplasmodial activity with IC50 of 7.3 μM.

Cell Viability Assay Cell Line:Larvae and neuronal cells (AW1) Concentration:6.25 μM, 12.5 μM, 25 μM, 50 μM and 100?μM Incubation Time:24 h, 48 h and 72 h Result:Had potential toxicity against H. zea both in vivo and in vitro via time- and dose-dependent manners. Cell Cycle Analysis Cell Line:Neuronal cells (AW1)Concentration:40 μM and 80 μM Incubation Time:24 h Result:The cell cycle was arrested at the G2/M phase.Apoptosis Analysis Cell Line:Neuronal cells (AW1)Concentration:20 μM, 40 μM, and 80 μM Incubation Time:24 h Result:Induced apoptosis via the mitochondrial pathway in AW1 cells.Western Blot Analysis Cell Line:Neuronal cells (AW1)Concentration:20 μM, 40 μM, and 80 μM Incubation Time:24 h Result:Showed upregulation of Bax/Bcl-2 expression resulting in the release of cytochrome c into the cytosol, activation of caspase-3/9, and cleavage of PARP.

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Apoptosis

PERK

ERK

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93859-63-3

542.49

C30H22O10

>98% (HPLC)

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O=C1[C@]([C@@H](OC=2C1=C(O)C=C(O)C2)C3=CC=C(O)C=C3)([C@@]4([C@H](OC=5C(C4=O)=C(O)C=C(O)C5)C6=CC=C(O)C=C6)[H])[H]

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(-20℃)

With Ice Pack

≥ 2 years