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PERK-IN-4

CAS No. 1337531-89-1

PERK-IN-4( —— )

Catalog No. M35065 CAS No. 1337531-89-1

PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM, used in the study of cancer and neurological disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 217 In Stock
25MG 394 In Stock
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100MG 798 In Stock
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Biological Information

  • Product Name
    PERK-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM, used in the study of cancer and neurological disorders.
  • Description
    PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    PERK
  • Recptor
    PERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1337531-89-1
  • Formula Weight
    469.43
  • Molecular Formula
    C24H19F4N5O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (44.37 mM; Ultrasonic )
  • SMILES
    Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cc(F)cc(c2)C(F)(F)F)c2c(N)ncnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Axten JM, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulu?
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