Inz-1
CAS No. 897776-15-7
Inz-1 ( Inz1;Inz 1 )
Catalog No. M27886 CAS No. 897776-15-7
Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 142 | Get Quote |
|
10MG | 239 | Get Quote |
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25MG | 430 | Get Quote |
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50MG | 628 | Get Quote |
|
100MG | 896 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameInz-1
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NoteResearch use only, not for human use.
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Brief DescriptionInz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human.
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DescriptionInz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.(In Vitro):Inz-1 against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively. Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively. Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM and only mildly at that concentration.
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SynonymsInz1;Inz 1
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorCarbonic anhydrase
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Research Area——
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Indication——
Chemical Information
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CAS Number897776-15-7
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Formula Weight266.3
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Molecular FormulaC16H14N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC(=O)Cn1nc(-c2ccccc2)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Milburn-McNulty P, et al. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD009472.
molnova catalog
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