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Indican

CAS No. 487-60-5

Indican( NSC-87517 | NSC 87517 | NSC87517 | Indoxyl-β-D-glucoside | 3-Indoxyl-beta-D-glucopyranoside )

Catalog No. M27182 CAS No. 487-60-5

Indican is a natural protective compound that is used to protect the liver.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Indican
  • Note
    Research use only, not for human use.
  • Brief Description
    Indican is a natural protective compound that is used to protect the liver.
  • Description
    Indican is a natural protective compound that is used to protect the liver.(In Vitro):Oral single doses of Indican at 20, 40 mg/kg increase the systemic exposure of MTX and MRT by inhibiting multiple anion transporters including OAT 1, OAT 3, and MRP 4 via the major metabolite indoxyl sulfate (IS) .
  • In Vitro
    ——
  • In Vivo
    Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS. Animal Model:Male Spraguee Dawley rats weighing 330-400 g Dosage:20, 40 mg/kg Administration:Orally Result:Increased the systemic exposure and multidrug resistance-associated protein (MRP) of Methotrexate (MTX; 5.0 mg/kg).
  • Synonyms
    NSC-87517 | NSC 87517 | NSC87517 | Indoxyl-β-D-glucoside | 3-Indoxyl-beta-D-glucopyranoside
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CCR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    487-60-5
  • Formula Weight
    295.291
  • Molecular Formula
    C14H17NO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (338.65 mM)
  • SMILES
    OC[C@H]1O[C@@H](Oc2c[nH]c3ccccc23)[C@H](O)[C@@H](O)[C@@H]1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Moree WJ, et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1869-73.
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