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Idarubicin

CAS No. 58957-92-9

Idarubicin ( 4-Demethoxydaunorubicin;IMI-30;NSC 256439 )

Catalog No. M15179 CAS No. 58957-92-9

Idarubicin (4-Demethoxydaunorubicin;IMI-30;NSC 256439) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Idarubicin
  • Note
    Research use only, not for human use.
  • Brief Description
    Idarubicin (4-Demethoxydaunorubicin;IMI-30;NSC 256439) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
  • Description
    Idarubicin (4-Demethoxydaunorubicin;IMI-30;NSC 256439) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells; inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM; also induces histone eviction from chromatin.Chemotherapeutic Agents Approved
  • Synonyms
    4-Demethoxydaunorubicin;IMI-30;NSC 256439
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topoisomerase
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    58957-92-9
  • Formula Weight
    497.49
  • Molecular Formula
    C26H27NO9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O
  • Chemical Name
    (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.
2. Pang B, et al. Nat Commun. 2013;4:1908.
3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.
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