ITZ-1( ITZ1 )

Catalog No. M10611 CAS No. 1180532-17-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ITZ-1
Note

Research use only, not for human use.
Brief Description

ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation.
Description

ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation; causes mild Raf-1 degradation, but scarcely induces degradation of a broad range of Hsp90 client proteins by binding to the Hsp90 C terminus; suppresses both IL-1β-induced proteoglycan and collagen release from bovine nasal cartilage in vitro and suppresses intra-articular infusion of IL-1β-induced cartilage proteoglycan degradation in rat knee joints.
In Vitro

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In Vivo

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Synonyms

ITZ1
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

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Indication

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CAS Number

1180532-17-5
Formula Weight

541.57
Molecular Formula

C20H20F5N3O3S3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-{(1Z)-5,6-Dimethyl3-oxo-8-[(4,4,5,5,5,-pentafluoropentyl)thio]-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-1-ylidene}-4methylbenzenesulfonamide

1. Kimura H, et al. Chem Biol. 2010 Jan 29;17(1):18-27. 2. Kimura H, et al. J Pharmacol Sci. 2009 Jun;110(2):201-11.

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