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KNK-437
CAS No. 218924-25-5
KNK-437( KNK437 )
Catalog No. M13492 CAS No. 218924-25-5
An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
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| 2MG | 32 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 70 | In Stock |
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| 25MG | 153 | In Stock |
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| 50MG | 228 | In Stock |
|
| 100MG | 342 | In Stock |
|
| 200MG | 548 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKNK-437
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NoteResearch use only, not for human use.
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Brief DescriptionAn inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.
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DescriptionAn inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells; inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibited at mRNA levels; shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200 mg/kg).Colon Cancer Preclinical.
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In Vitro——
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In Vivo——
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SynonymsKNK437
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP105|HSP40|HSP72
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Research AreaCancer
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IndicationColon Cancer
Chemical Information
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CAS Number218924-25-5
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Formula Weight245.2307
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Molecular FormulaC13H11NO4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 34 mg/mL
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SMILESO=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O
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Chemical Name1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yokota S, et al. Cancer Res. 2000 Jun 1;60(11):2942-8.
2. Koishi M, et al. Clin Cancer Res. 2001 Jan;7(1):215-9.
3. Guo F, et al. Cancer Res. 2005 Nov 15;65(22):10536-44.
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