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IRAK4-IN-1
CAS No. 1820787-94-7
IRAK4-IN-1( —— )
Catalog No. M17387 CAS No. 1820787-94-7
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
|
| 10MG | 215 | In Stock |
|
| 25MG | 439 | In Stock |
|
| 50MG | 641 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 500MG | 1782 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIRAK4-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionIRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
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DescriptionIRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
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In VitroThe in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB) .
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In VivoOral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance(Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorIRAK-4
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Research Area——
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Indication——
Chemical Information
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CAS Number1820787-94-7
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Formula Weight337.42
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Molecular FormulaC19H23N5O
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Purity>98% (HPLC)
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SolubilityDMSO : 14.29 mg/mL 42.35 mM; H2O : < 0.1 mg/mL
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SMILESN#Cc1cc2c(ncnc2N[C@@H]2CC[C@@H](N3CCOCC3)CC2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.
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