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IR415

CAS No. 452967-14-5

IR415 ( IR 415;IR-415 )

Catalog No. M14538 CAS No. 452967-14-5

IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
2MG	35	Get Quote
5MG	58	Get Quote
10MG	102	Get Quote
25MG	205	Get Quote
50MG	357	Get Quote
100MG	530	Get Quote
200MG	Get Quote	Get Quote
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Biological Information

Product Name

IR415
Note

Research use only, not for human use.
Brief Description

IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression.
Description

IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner.
Synonyms

IR 415;IR-415
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

——
Indication

——

Chemical Information

CAS Number

452967-14-5
Formula Weight

296.34
Molecular Formula

C13H14F2N4S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

N-(2,4-difluorophenyl)-N'-[3-(1H-imidazol-1-yl) propyl] thiourea

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ghosh S, et al. J Biol Chem. 2017 Jul 28;292(30):12577-12588.

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