Cart
sales@molnova.com
INH14
CAS No. 200134-22-1
INH14( —— )
Catalog No. M20088 CAS No. 200134-22-1
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 77 | In Stock |
|
| 10MG | 113 | In Stock |
|
| 25MG | 186 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameINH14
-
NoteResearch use only, not for human use.
-
Brief DescriptionINH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
-
DescriptionINH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
-
In Vitro——
-
In VivoINH14 (5 μg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice. Animal Model:8-week old, male, pathogen-free C57BL/6J mice Dosage:5 μg/g, one hour before Pam2CSK4 injection Administration:I.P. for 2 hours Result:Decreased TNFα production in mice.
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetIκB kinase (IKK)
-
RecptorIKKα| IKKβ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number200134-22-1
-
Formula Weight240.3
-
Molecular FormulaC15H16N2O
-
Purity>98% (HPLC)
-
SolubilityDMSO: 100 mg/mL (416.14 mM)
-
SMILESCCc1ccc(NC(=O)Nc2ccccc2)cc1
-
Chemical NameN-(4-Ethylphenyl)-N'-phenylurea
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Drexel M et al. INH14 a Small-Molecule Urea Derivative Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.
molnova catalog
related products
-
IKK2-IN-9
IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM.
-
IMD-0354
A potent, selective IKKβ inhibitor that inhibits NF-κB activity both in vitro and in vivo.
-
Bay 65-1942 hydrochl...
A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM.
