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IKK2-IN-9
CAS No. 1266240-89-4
IKK2-IN-9( —— )
Catalog No. M11120 CAS No. 1266240-89-4
IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIKK2-IN-9
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NoteResearch use only, not for human use.
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Brief DescriptionIKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM.
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DescriptionIKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIκB kinase (IKK)
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Research Area——
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Indication——
Chemical Information
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CAS Number1266240-89-4
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Formula Weight394.497
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Molecular FormulaC20H22N6OS
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(S)-N-(1-(3-(5-(ethylamino)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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BOT-64
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compoundBOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB.?
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BAY-985
BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 (IC50s: 123, 276, 311, and 7930 nM). BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3, IC50: 74 nM).
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WS-6
A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM.
