
IMB-301
CAS No. 64009-84-3
IMB-301( IMB301 | NSC 301209 )
Catalog No. M15432 CAS No. 64009-84-3
IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 178 | Get Quote |
![]() ![]() |
10MG | 295 | Get Quote |
![]() ![]() |
25MG | 502 | Get Quote |
![]() ![]() |
50MG | 709 | Get Quote |
![]() ![]() |
100MG | 1008 | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameIMB-301
-
NoteResearch use only, not for human use.
-
Brief DescriptionIMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex.
-
DescriptionIMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM); restores hA3G expression in the presence of Vif through disruption of the Vif-hA3G interaction, significantly increases the amount of hA3G-HA in the virions; directly binds to hA3G with of 15.6 uM.
-
In VitroIMB-301 is able to increase virion encapsidation of hA3G via its ability to impair the degradation of hA3Gby Vif, which results in hA3G-dependent anti-HIV activity. IMB-301 binds to hA3G, restores hA3G expression in the presence of Vif, and inhibits the replication of HIV-1 in a hA3G-dependent manner.
-
In Vivo——
-
SynonymsIMB301 | NSC 301209
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number64009-84-3
-
Formula Weight379.256
-
Molecular FormulaC19H17Cl2FN2O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (263.67 mM)
-
SMILESC1=CC(=CC=C1OCCC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)F
-
Chemical Name1-(2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl)-1H-imidazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ma L, et al. Sci Rep. 2018 May 23;8(1):8067.
molnova catalog



related products
-
Efavirenz
A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.
-
Terameprocol
Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.
-
Nevirapine
A potent and specific non-nucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 0.2 uM.