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ICA069673

CAS No. 582323-16-8

ICA069673( ICA-069673 | ICA 069673 | ICA069673 )

Catalog No. M17548 CAS No. 582323-16-8

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ICA069673
  • Note
    Research use only, not for human use.
  • Brief Description
    ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
  • Description
    ICA069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively). ICA-069673 inhibited spontaneous phasic, pharmacologically induced, and nerve-evoked contractions in DSM isolated strips in a concentration-dependent manner. ICA-069673 decreased the global intracellular Ca(2+) concentration in DSM cells, an effect blocked by the L-type Ca(2+) channel inhibitor nifedipine. ICA-069673 hyperpolarized the membrane potential and inhibited spontaneous action potentials of isolated DSM cells, effects that were blocked in the presence of XE991.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ICA-069673 | ICA 069673 | ICA069673
  • Pathway
    Angiogenesis
  • Target
    FAK
  • Recptor
    KCNQ2/Q3 potassium channel
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    582323-16-8
  • Formula Weight
    269.63
  • Molecular Formula
    C11H6CLF2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 34 mg/mL; 126.10 mM
  • SMILES
    c1cc(c(cc1C(=O)Nc1cnc(nc1)Cl)F)F
  • Chemical Name
    N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wickenden AD, et al. Mol Pharmacol. 2008 Mar;73(3):977-86. Epub 2007 Dec 18.
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