HhAntag ( HhAntag; Hh-Antag; Hh Antag )

Catalog No. M17525 CAS No. 496794-70-8

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Product Name

HhAntag
Note

Research use only, not for human use.
Brief Description

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.
Description

HhAntag is a GLI1-mediated transcription inhibitor. It acts as an inhibitor of the Shh pathway.
Synonyms

HhAntag; Hh-Antag; Hh Antag
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

Gli
Research Area

Cancer
Indication

——

CAS Number

496794-70-8
Formula Weight

450.92
Molecular Formula

C24H23ClN4O3
Purity

96%
Solubility

DMSO : ≥ 100 mg/mL. 221.77 mM; H2O : < 0.1 mg/mL
SMILES

C(=O)(c1cc(cc(c1)OC)OC)Nc1cc(c(cc1)Cl)c1nc2c([nH]1)cc(cc2)N(C)C
Chemical Name

N-[4-Chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide

1.Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. Biopolymers (2011), 95(1), 24-30.

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