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Hetrombopag

CAS No. 2114365-78-3

Hetrombopag( —— )

Catalog No. M13363 CAS No. 2114365-78-3

Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hetrombopag
  • Note
    Research use only, not for human use.
  • Brief Description
    Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist.
  • Description
    Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo.Other Indication Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    CD110
  • Recptor
    CD110
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    2114365-78-3
  • Formula Weight
    458.474
  • Molecular Formula
    C25H22N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMF : 6.25 mg/mL (13.63 mM)
  • SMILES
    CC1=C(C(=O)N(N1)C2=CC3=C(CCCC3)C=C2)N=NC4=CC=CC(=C4O)C5=CC=C(O5)C(=O)O
  • Chemical Name
    5-[(5E)-5-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]furan-2-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou N, et al. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577. 2. Xie C, et al. J Cell Mol Med. 2018 Nov;22(11):5367-5377.
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    Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist.

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