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HTH-01-015
CAS No. 1613724-42-7
HTH-01-015( HTH 01 015 )
Catalog No. M12346 CAS No. 1613724-42-7
HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 97 | In Stock |
|
| 25MG | 201 | In Stock |
|
| 50MG | 286 | In Stock |
|
| 100MG | 385 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHTH-01-015
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NoteResearch use only, not for human use.
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Brief DescriptionHTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM.
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DescriptionHTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2; also does not markedly suppress the activity of any of the other 139 protein kinases, including AMPK; suppresses NUAK1-mediated MYPT1 phosphorylation in vivo, the NUAK1 mutation (A195T) renders resistant to HTH-01-015; significantly inhibits migration the proliferation of MEFs (mouse embryonic fibroblasts).
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In Vitro——
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In Vivo——
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SynonymsHTH 01 015
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorNUAK1|NUAK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1613724-42-7
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Formula Weight468.5535
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Molecular FormulaC26H28N8O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1
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Chemical Name6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Banerjee S, et al. Biochem J. 2014 Jan 1;457(1):215-25.
2. Banerjee S, et al. Biochem J. 2014 Jul 15;461(2):233-45.
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