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HS-72
CAS No. 1800285-51-1
HS-72( HS72 )
Catalog No. M12733 CAS No. 1800285-51-1
HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHS-72
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NoteResearch use only, not for human use.
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Brief DescriptionHS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72).
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DescriptionHS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity.
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In Vitro——
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In Vivo——
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SynonymsHS72
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1800285-51-1
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Formula Weight364.44
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Molecular FormulaC20H24N6O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59.
2. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92.
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