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HS-72

CAS No. 1800285-51-1

HS-72( HS72 )

Catalog No. M12733 CAS No. 1800285-51-1

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HS-72
  • Note
    Research use only, not for human use.
  • Brief Description
    HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72).
  • Description
    HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HS72
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1800285-51-1
  • Formula Weight
    364.44
  • Molecular Formula
    C20H24N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59. 2. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92.
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