Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - HDAC - CHR-3996

CHR-3996

CAS No. 1256448-47-1

CHR-3996( Nanatinostat | CHR3996 | VRx-3996 | Tractinostat )

Catalog No. M11049 CAS No. 1256448-47-1

CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 428 Get Quote
50MG 1791 Get Quote
100MG 2682 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    CHR-3996
  • Note
    Research use only, not for human use.
  • Brief Description
    CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
  • Description
    CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3; displays little to no activity against HDAC5 and HDAC6 (IC50=200-2000 nM); demonstrates growth inhibition of HCT116 cells with GI50 of 72 nM, shows efficacy in human tumor xenograft and exhibits good activity in combination with other anticancer agents.Blood Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Nanatinostat | CHR3996 | VRx-3996 | Tractinostat
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1256448-47-1
  • Formula Weight
    394.41
  • Molecular Formula
    C20H19FN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (126.77 mM)
  • SMILES
    O=C(C1=CN=C(N2C[C@]3([H])[C@@H](NCC4=NC5=CC=C(F)C=C5C=C4)[C@]3([H])C2)N=C1)NO
  • Chemical Name
    2-[(1R,5S,6s)-6-{[(6-fluoroquinolin-2-yl)methyl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-N-hydroxypyrimidine-5-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Moffat D, J Med Chem. 2010 Dec 23;53(24):8663-78. 2. Banerji U, et al. Clin Cancer Res. 2012 May 1;18(9):2687-94. 3. Smith EM, et al. Oncotarget. 2015 Jul 10;6(19):17314-27.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CUDC-101

    A potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.

  • Resminostat hydrochl...

    A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).

  • Panobinostat

    A potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.

Sign In Join Free