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CHR-3996
CAS No. 1256448-47-1
CHR-3996( Nanatinostat | CHR3996 | VRx-3996 | Tractinostat )
Catalog No. M11049 CAS No. 1256448-47-1
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 428 | Get Quote |
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| 50MG | 1791 | Get Quote |
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| 100MG | 2682 | Get Quote |
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| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCHR-3996
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NoteResearch use only, not for human use.
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Brief DescriptionCHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
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DescriptionCHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3; displays little to no activity against HDAC5 and HDAC6 (IC50=200-2000 nM); demonstrates growth inhibition of HCT116 cells with GI50 of 72 nM, shows efficacy in human tumor xenograft and exhibits good activity in combination with other anticancer agents.Blood Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsNanatinostat | CHR3996 | VRx-3996 | Tractinostat
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1256448-47-1
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Formula Weight394.41
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Molecular FormulaC20H19FN6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (126.77 mM)
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SMILESO=C(C1=CN=C(N2C[C@]3([H])[C@@H](NCC4=NC5=CC=C(F)C=C5C=C4)[C@]3([H])C2)N=C1)NO
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Chemical Name2-[(1R,5S,6s)-6-{[(6-fluoroquinolin-2-yl)methyl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-N-hydroxypyrimidine-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Moffat D, J Med Chem. 2010 Dec 23;53(24):8663-78.
2. Banerji U, et al. Clin Cancer Res. 2012 May 1;18(9):2687-94.
3. Smith EM, et al. Oncotarget. 2015 Jul 10;6(19):17314-27.
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