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Home - Products - Cell Cycle/DNA Damage - HDAC - CHR-3996

CHR-3996

CAS No. 1256448-47-1

CHR-3996 ( Nanatinostat;CHR3996;VRx-3996;Tractinostat )

Catalog No. M11049 CAS No. 1256448-47-1

CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CHR-3996
  • Note
    Research use only, not for human use.
  • Brief Description
    CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
  • Description
    CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3; displays little to no activity against HDAC5 and HDAC6 (IC50=200-2000 nM); demonstrates growth inhibition of HCT116 cells with GI50 of 72 nM, shows efficacy in human tumor xenograft and exhibits good activity in combination with other anticancer agents.Blood Cancer Phase 2 Clinical
  • Synonyms
    Nanatinostat;CHR3996;VRx-3996;Tractinostat
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1256448-47-1
  • Formula Weight
    394.41
  • Molecular Formula
    C20H19FN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CN=C(N2C[C@]3([H])[C@@H](NCC4=NC5=CC=C(F)C=C5C=C4)[C@]3([H])C2)N=C1)NO
  • Chemical Name
    2-[(1R,5S,6s)-6-{[(6-fluoroquinolin-2-yl)methyl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-N-hydroxypyrimidine-5-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Moffat D, J Med Chem. 2010 Dec 23;53(24):8663-78.
2. Banerji U, et al. Clin Cancer Res. 2012 May 1;18(9):2687-94.
3. Smith EM, et al. Oncotarget. 2015 Jul 10;6(19):17314-27.
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