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HL001
CAS No. 1186371-31-2
HL001( HL 001 )
Catalog No. M10634 CAS No. 1186371-31-2
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHL001
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NoteResearch use only, not for human use.
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Brief DescriptionHL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM.
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DescriptionHL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression; stabilizes p53 through inhibiting the MDM2-mediated p53 ubiquitination, and downregulates G3BP1 and induces ROS and DNA damage; selectively suppresses tumor growth in p53 wild-type NSCLC harboring p53-72R through disrupting interaction between MDM2 and p53-72R in a CypA-dependent manner; synergistically enhance tumor regression in orthotopic NSCLC mouse model combined with cisplatin.
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In Vitro——
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In Vivo——
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SynonymsHL 001
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1186371-31-2
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Formula Weight360.369
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Molecular FormulaC21H16N2O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-((9H-fluoren-9-yl)carbamoyl)-2,6-dihydroxybenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu W, et al. Oncogene. 2017 Aug 17;36(33):4719-4731.
2. Ni S, et al. J Med Chem. 2009 Sep 10;52(17):5295-8.
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