MPT0G211
CAS No. 2151853-97-1
MPT0G211 ( —— )
Catalog No. M13434 CAS No. 2151853-97-1
MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
50MG | 888 | Get Quote |
|
100MG | 1251 | Get Quote |
|
200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameMPT0G211
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NoteResearch use only, not for human use.
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Brief DescriptionMPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM.
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DescriptionMPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms; significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation, significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins; ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region; also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2151853-97-1
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Formula Weight293.33
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Molecular FormulaC17H15N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC2=C(C(=C1)NCC3=CC=C(C=C3)C(=O)NO)N=CC=C2
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Chemical NameN-hydroxy-4-((quinolin-8-ylamino)methyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fan SJ, et al. Cell Death Dis. 2018 May 29;9(6):655.
2. Lee HY, et al. J Med Chem. 2018 Feb 8;61(3):905-917.
2. Lee HY, et al. J Med Chem. 2018 Feb 8;61(3):905-917.
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