MPT0G211

CAS No. 2151853-97-1

MPT0G211 ( —— )

Catalog No. M13434 CAS No. 2151853-97-1

MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MPT0G211
  • Note
    Research use only, not for human use.
  • Brief Description
    MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM.
  • Description
    MPT0G211 is a novel potent, selective HDAC6 inhibitor with IC50 of 0.291 nM, displays >1,000-fold selectivity over other HDAC isoforms; significantly inhibits tau phosphorylation on Ser396, Ser404, and phosphorylated tau (p-tau) aggregation, significantly attenuates apoptosis induced by p-tau, inhibits HDAC6/Hsp90 binding and causes subsequent proteasomal degradation of polyubiquitinated proteins; ameliorates learning and memory impairment in animal models of Alzheimer's disease, reduces the amount of phosphorylated tau in the hippocampal CA1 region; also demonstrates antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2151853-97-1
  • Formula Weight
    293.33
  • Molecular Formula
    C17H15N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC2=C(C(=C1)NCC3=CC=C(C=C3)C(=O)NO)N=CC=C2
  • Chemical Name
    N-hydroxy-4-((quinolin-8-ylamino)methyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fan SJ, et al. Cell Death Dis. 2018 May 29;9(6):655.
2. Lee HY, et al. J Med Chem. 2018 Feb 8;61(3):905-917.
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