HDAC8-IN-22d
CAS No. 1417997-93-3
HDAC8-IN-22d ( HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933 )
Catalog No. M11745 CAS No. 1417997-93-3
HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 59 | In Stock |
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5MG | 91 | In Stock |
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10MG | 139 | In Stock |
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25MG | 278 | In Stock |
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50MG | 431 | In Stock |
|
100MG | 550 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameHDAC8-IN-22d
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NoteResearch use only, not for human use.
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Brief DescriptionHDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.
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DescriptionHDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
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SynonymsHDAC8-IN-1; MDK-7933; MDK 7933; MDK7933
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC8
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Research Area——
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Indication——
Chemical Information
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CAS Number1417997-93-3
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Formula Weight345.40
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Molecular FormulaC22H19NO3
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Purity>98% (HPLC)
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SolubilityDMSO: 130 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
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Chemical Name(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang WJ, et al. ChemMedChem. 2012 Oct;7(10):1815-24.
molnova catalog
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