HDAC8-IN-22d

CAS No. 1417997-93-3

HDAC8-IN-22d ( HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933 )

Catalog No. M11745 CAS No. 1417997-93-3

HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 59 In Stock
5MG 91 In Stock
10MG 139 In Stock
25MG 278 In Stock
50MG 431 In Stock
100MG 550 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    HDAC8-IN-22d
  • Note
    Research use only, not for human use.
  • Brief Description
    HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.
  • Description
    HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.
  • Synonyms
    HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1417997-93-3
  • Formula Weight
    345.40
  • Molecular Formula
    C22H19NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 130 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
  • Chemical Name
    (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang WJ, et al. ChemMedChem. 2012 Oct;7(10):1815-24.
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