HDAC8-IN-22d

Research use only, not for human use.

HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM.

HDAC8-IN-22d is a potent, selective HDAC8 inhibitor with IC50 of 27.2 nM, exhibits no activity against other HDACs and limited activity against HDAC1 and 3; shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); exhibits cytotoxicity against human lung CL1-5 cells (IC50=7.0 uM) similar to that of SAHA yet without significant cytotoxicity for normal IMR-90 cells.

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.

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HDAC8-IN-1 | MDK-7933 | MDK 7933 | MDK7933

Cell Cycle/DNA Damage

HDAC

HDAC8

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1417997-93-3

345.398

C22H19NO3

>98% (HPLC)

DMSO: 130 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O

(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide

(-20℃)

With Ice Pack

≥ 2 years