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Entinostat
CAS No. 209783-80-2
Entinostat ( MS-275;SNDX-275;MS 275;SNDX 275 )
Catalog No. M13310 CAS No. 209783-80-2
A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 45 | In Stock |
|
| 25MG | 65 | In Stock |
|
| 50MG | 81 | In Stock |
|
| 100MG | 113 | In Stock |
|
| 200MG | 174 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEntinostat
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
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DescriptionA potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3; no inhibition on HDAC8/4/5/7/9/6/10 (IC50>10 uM); induces accumulation of p21WAF1/CIP1 and gelsolin in K562 cell; reduce S-phase cells and induce G1-phase cells in A2780 cell.Breast Cancer Phase 3 Clinical
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SynonymsMS-275;SNDX-275;MS 275;SNDX 275
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC3
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number209783-80-2
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Formula Weight376.41
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Molecular FormulaC21H20N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OCC1=CC=CN=C1)NCC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2
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Chemical NameCarbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Saito A, et al. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7.
2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.
3. Rosato RR, et al. Cancer Res, 2003, 63(13), 3637-3645.
2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.
3. Rosato RR, et al. Cancer Res, 2003, 63(13), 3637-3645.
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