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Entinostat

CAS No. 209783-80-2

Entinostat ( MS-275;SNDX-275;MS 275;SNDX 275 )

Catalog No. M13310 CAS No. 209783-80-2

A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 65 In Stock
50MG 81 In Stock
100MG 113 In Stock
200MG 174 In Stock
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Biological Information

  • Product Name
    Entinostat
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
  • Description
    A potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3; no inhibition on HDAC8/4/5/7/9/6/10 (IC50>10 uM); induces accumulation of p21WAF1/CIP1 and gelsolin in K562 cell; reduce S-phase cells and induce G1-phase cells in A2780 cell.Breast Cancer Phase 3 Clinical
  • Synonyms
    MS-275;SNDX-275;MS 275;SNDX 275
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC3
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    209783-80-2
  • Formula Weight
    376.41
  • Molecular Formula
    C21H20N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(OCC1=CC=CN=C1)NCC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2
  • Chemical Name
    Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Saito A, et al. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7.
2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.
3. Rosato RR, et al. Cancer Res, 2003, 63(13), 3637-3645.
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