HDAC6-IN-9( —— )

Catalog No. M35480 CAS No. 2796282-58-9

HDAC6-IN-9 is an orally active and highly effective γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.

Purity : >98% (HPLC)

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Biological Information

Product Name

HDAC6-IN-9
Note

Research use only, not for human use.
Brief Description

HDAC6-IN-9 is an orally active and highly effective γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.
Description

HDAC6-IN-9 (compound 12c) is a potent and selective HDAC6 inhibitor with IC50 values of 11.8, 15.2, 4.2, 139.6, 21.3 nM for HDAC1,HDAC3, HDAC6, HDAC8, HDAC10, respectively. HDAC6-IN-9 shows anti-proliferative activities.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Neuroscience
Target

Gamma-secretase
Recptor

Gamma-secretase
Research Area

——
Indication

——

Chemical Information

CAS Number

2796282-58-9
Formula Weight

320.34
Molecular Formula

C19H16N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NO)C1=CC=C(C=C1)CC(=O)NC=2C=CC=3C=CC=CC3C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Li X,et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 Aug;125:105874.?

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