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HC-067047

CAS No. 883031-03-6

HC-067047 ( HC-067047; HC 067047; HC067047 )

Catalog No. M19226 CAS No. 883031-03-6

HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HC-067047
  • Note
    Research use only, not for human use.
  • Brief Description
    HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
  • Description
    HC-067047 is a potent and selective TRPV4 antagonist. HC-067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis. HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. HC-067047 may provide a promising means of treating bladder
  • Synonyms
    HC-067047; HC 067047; HC067047
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hTRPV4/mTRPV4
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    883031-03-6
  • Formula Weight
    471.51
  • Molecular Formula
    C26H28F3N3O2
  • Purity
    98%
  • Solubility
    DMSO : 50 mg/mL 106.04 mM;
  • SMILES
    FC(F)(F)c1cc(ccc1)NC(=O)c4cc(c2ccccc2)n(CCCN3CCOCC3)c4C
  • Chemical Name
    2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.
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