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HC-067047
CAS No. 883031-03-6
HC-067047 ( HC-067047; HC 067047; HC067047 )
Catalog No. M19226 CAS No. 883031-03-6
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 56 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 295 | In Stock |
|
| 100MG | 475 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHC-067047
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NoteResearch use only, not for human use.
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Brief DescriptionHC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
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DescriptionHC-067047 is a potent and selective TRPV4 antagonist. HC-067047 increases functional bladder capacity and reduces micturition frequency in WT mice and rats with cystitis. HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. HC-067047 may provide a promising means of treating bladder
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SynonymsHC-067047; HC 067047; HC067047
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PathwayOthers
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TargetOther Targets
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RecptorhTRPV4/mTRPV4
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number883031-03-6
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Formula Weight471.51
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Molecular FormulaC26H28F3N3O2
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Purity98%
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SolubilityDMSO : 50 mg/mL 106.04 mM;
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SMILESFC(F)(F)c1cc(ccc1)NC(=O)c4cc(c2ccccc2)n(CCCN3CCOCC3)c4C
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Chemical Name2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9.
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