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HA-130
CAS No. 1229652-21-4
HA-130( HA130 | HA 130 )
Catalog No. M10904 CAS No. 1229652-21-4
A potent and selective inhibitor of autotaxin with IC50 of 28 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
|
| 5MG | 47 | In Stock |
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| 10MG | 77 | In Stock |
|
| 25MG | 133 | In Stock |
|
| 50MG | 222 | In Stock |
|
| 100MG | 333 | In Stock |
|
| 200MG | 500 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHA-130
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of autotaxin with IC50 of 28 nM.
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DescriptionA potent and selective inhibitor of autotaxin with IC50 of 28 nM; shows no effect on chymotryptic, caspase, and tryptic activities of the proteasome, alkaline phosphatase and a broad-spectrum PEDs (IC50>10 uM); inhibits ATX-driven melanoma cell migration and decreases circulating LPA levels in mice.
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In VitroHA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.
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In VivoHA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle.The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).
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SynonymsHA130 | HA 130
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PathwayWnt/Notch/Hedgehog
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TargetAutotaxin
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RecptorATX(autotaxin)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1229652-21-4
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Formula Weight463.2858
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Molecular FormulaC24H19BFNO5S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 39 mg/mL
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SMILESOB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O
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Chemical NameBoronic acid, B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Albers HM, et al. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7257-62.
2. Zhang Y, et al. J Immunol. 2012 Oct 15;189(8):3914-24.
3. Lai SL, et al. Development. 2012 Dec 1;139(23):4439-48.
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HA-130
A potent and selective inhibitor of autotaxin with IC50 of 28 nM.
