Gilteritinib ( ASP2215;ASP-2215 )

Catalog No. M11028 CAS No. 1254053-43-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Gilteritinib
Note

Research use only, not for human use.
Brief Description

A potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively.
Description

A potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively), and shows >800-fold selectivity over c-Kit; inhibits the growth of Ba/F3 cells expressing either FLT3-ITD, FLT3-D835Y, FLT3-ITD-D835Y, FLT3-ITD-F691 L, and FLT3-ITD-F691I, with IC50 of 1.8 nM, 1.6 nM, 2.1 nM, 22 nM, and 49 nM, respectively; orally bioactive.Blood Cancer Phase 3 Clinical
Synonyms

ASP2215;ASP-2215
Pathway

Tyrosine Kinase
Target

FLT3
Recptor

FLT3;AXL
Research Area

Cancer
Indication

Blood cancer

CAS Number

1254053-43-4
Formula Weight

552.71
Molecular Formula

C29H44N8O3
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5
Chemical Name

2-Pyrazinecarboxamide, 6-ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-

1. Mori M, et al. Invest New Drugs. 2017 May 17. doi: 10.1007/s10637-017-0470-z.
2. Lee LY, et al. Blood. 2017 Jan 12;129(2):257-260.

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