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Quizartinib

CAS No. 950769-58-1

Quizartinib ( AC-220;AC220 )

Catalog No. M16800 CAS No. 950769-58-1

Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Quizartinib
  • Note
    Research use only, not for human use.
  • Brief Description
    Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM.
  • Description
    Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively; displays excellent kinase selectivity in a KinomeScan panel of 402 kinase binding assays, also potently inhibits PDGFRA, PDGFRB and RET; inhibits MV4-11 cell proliferarion with IC50 of 0.56 nM, demonstrates antitumor efficacy in the MV4-11 tumor xenograft model.Blood Cancer Phase 3 Clinical
  • Synonyms
    AC-220;AC220
  • Pathway
    Tyrosine Kinase
  • Target
    FLT3
  • Recptor
    FLT3(ITD);FLT3(WT);FLT3
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    950769-58-1
  • Formula Weight
    560.67
  • Molecular Formula
    C29H32N6O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C=C2)C2=CN3C(SC4=C3C=CC(OCCN3CCOCC3)=C4)=N2)=NO1
  • Chemical Name
    Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zarrinkar PP, et al. Blood. 2009 Oct 1;114(14):2984-92.
2. Chao Q, et al. J Med Chem. 2009 Dec 10;52(23):7808-16.
3. Pratz KW, et al. Blood. 2010 Feb 18;115(7):1425-32.
4. Gunawardane RN, et al. Mol Cancer Ther. 2013 Apr;12(4):438-47.
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