Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - PARP - Gemcabene

Gemcabene

CAS No. 183293-82-5

Gemcabene( PD-72953 | PD72953 )

Catalog No. M12827 CAS No. 183293-82-5

Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 64 Get Quote
5MG 98 Get Quote
10MG 165 Get Quote
25MG 303 Get Quote
50MG 503 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Gemcabene
  • Note
    Research use only, not for human use.
  • Brief Description
    Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP.
  • Description
    Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP; down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM; lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.Hypercholesterolemia Phase 2 Clinical.
  • In Vitro
    Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2).
  • In Vivo
    ——
  • Synonyms
    PD-72953 | PD72953
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypercholesterolemia

Chemical Information

  • CAS Number
    183293-82-5
  • Formula Weight
    302.411
  • Molecular Formula
    C16H30O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (330.68 mM)
  • SMILES
    O=C(O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O
  • Chemical Name
    6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bisgaier CL, et al. J Lipid Res. 1998 Jan;39(1):17-30. 2. Bays HE, et al. Am J Cardiol. 2003 Sep 1;92(5):538-43. 3. Yuan H, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):191-7. 4. Srivastava RAK, et al. Front Pharmacol. 2018 May 11;9:471.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AZ9482

    AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.

  • Talazoparib tosylate

    Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).

  • 5-amino-1,2-dihydroi...

    5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.

Sign In Join Free