Gboxin ( Gboxin; Gboxin chloride )

Catalog No. M13335 CAS No. 2101315-36-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Gboxin
Note

Research use only, not for human use.
Brief Description

Gboxin is a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM).
Description

Gboxin is a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells (primary GBM IC50=150 nM) but not that of mouse embryonic fibroblasts or neonatal astrocytes; Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma, inhibits the activity of F0F1 ATP synthase, mirrors oligomycin activity and resistance requires functional mPTP.
Synonyms

Gboxin; Gboxin chloride
Pathway

Endocrinology/Hormones
Target

ATPase
Recptor

ATPase
Research Area

——
Indication

——

CAS Number

2101315-36-8
Formula Weight

392.97
Molecular Formula

C22H33ClN2O2
Purity

>98% (HPLC)
Solubility

DMSO : 32.5 mg/mL 82.71 mM
SMILES

C[N+]1=C(CC)N(CC(O[C@H]2[C@H](C(C)C)CC[C@@H](C)C2)=O)C3=CC=CC=C31.[Cl-]
Chemical Name

2-ethyl-1-(2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-3-methyl-1H-benzo[d]imidazol-3-ium chloride

1. Shi Y, et al. Nature. 2019 Mar;567(7748):341-346.

Calculator

molnova catalog