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GW-6604
CAS No. 452342-37-9
GW-6604( GW6604 | GW 6604 )
Catalog No. M14536 CAS No. 452342-37-9
A TGF-beta signaling pathway inhibitor that tagets ALK5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 295 | Get Quote |
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| 50MG | 440 | Get Quote |
|
| 100MG | 642 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGW-6604
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NoteResearch use only, not for human use.
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Brief DescriptionA TGF-beta signaling pathway inhibitor that tagets ALK5.
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DescriptionA TGF-beta signaling pathway inhibitor that tagets ALK5; inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay; increases liver regeneration in TGF-beta-overexpressing mice at 40 mg kg(-1) p.o.
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In Vitro——
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In Vivo——
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SynonymsGW6604 | GW 6604
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFBR
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Research Area——
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Indication——
Chemical Information
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CAS Number452342-37-9
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Formula Weight298.34
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Molecular FormulaC19H14N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (335.19 mM)
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SMILESC1(C2=CC=CC=C2)=NC=CC(C3=CNN=C3C4=NC=CC=C4)=C1
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Chemical Name2-Phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. de Gouville AC, et al. Br J Pharmacol. 2005 May;145(2):166-77.
2. de Gouville AC, et al. Drug News Perspect. 2006 Mar;19(2):85-90.
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