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GW-6604

CAS No. 452342-37-9

GW-6604( GW6604 | GW 6604 )

Catalog No. M14536 CAS No. 452342-37-9

A TGF-beta signaling pathway inhibitor that tagets ALK5.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GW-6604
  • Note
    Research use only, not for human use.
  • Brief Description
    A TGF-beta signaling pathway inhibitor that tagets ALK5.
  • Description
    A TGF-beta signaling pathway inhibitor that tagets ALK5; inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay; increases liver regeneration in TGF-beta-overexpressing mice at 40 mg kg(-1) p.o.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GW6604 | GW 6604
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    TGFBR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    452342-37-9
  • Formula Weight
    298.34
  • Molecular Formula
    C19H14N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (335.19 mM)
  • SMILES
    C1(C2=CC=CC=C2)=NC=CC(C3=CNN=C3C4=NC=CC=C4)=C1
  • Chemical Name
    2-Phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Gouville AC, et al. Br J Pharmacol. 2005 May;145(2):166-77. 2. de Gouville AC, et al. Drug News Perspect. 2006 Mar;19(2):85-90.
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