GW-6604

CAS No. 452342-37-9

GW-6604( GW6604 | GW 6604 )

Catalog No. M14536 CAS No. 452342-37-9

A TGF-beta signaling pathway inhibitor that tagets ALK5.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 110 Get Quote
10MG 177 Get Quote
25MG 295 Get Quote
50MG 440 Get Quote
100MG 642 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    GW-6604
  • Note
    Research use only, not for human use.
  • Brief Description
    A TGF-beta signaling pathway inhibitor that tagets ALK5.
  • Description
    A TGF-beta signaling pathway inhibitor that tagets ALK5; inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay; increases liver regeneration in TGF-beta-overexpressing mice at 40 mg kg(-1) p.o.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GW6604 | GW 6604
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    TGFBR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    452342-37-9
  • Formula Weight
    298.34
  • Molecular Formula
    C19H14N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (335.19 mM)
  • SMILES
    C1(C2=CC=CC=C2)=NC=CC(C3=CNN=C3C4=NC=CC=C4)=C1
  • Chemical Name
    2-Phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Gouville AC, et al. Br J Pharmacol. 2005 May;145(2):166-77. 2. de Gouville AC, et al. Drug News Perspect. 2006 Mar;19(2):85-90.
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