Cart
sales@molnova.com
AZ12601011
CAS No. ——
AZ12601011( AZ-12601011 | AZ 12601011 )
Catalog No. M16993 CAS No. ——
AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAZ12601011
-
NoteResearch use only, not for human use.
-
Brief DescriptionAZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM).
-
DescriptionAZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM; inhibits TGFBR1 kinase activity (competition binding) with Kd of 2.9 nM, shows some inhibitory activity against the related receptors ALK4 and BMPR1B, but shows only weakly activity against ALK1, ALK2 and BMPR1A in in vitro kinase assays; AZ12601011 is a more effective inhibitor of TGFβ-induced reporter activity than SB-431542 (IC50=84nM) and LY2157299 (galunisertib) (IC50=380nM), inhibits phosphorylation of SMAD2 via the type 1 receptors ALK4, TGFBR1 and ALK7; AZ12601011 is highly effective at inhibiting basal and TGFβ-induced migration of HaCaT keratinocytes, inhibits tumour growth and metastasis to the lungs in a 4T1 syngeneic orthotopic mammary tumour model.
-
In Vitro——
-
In Vivo——
-
SynonymsAZ-12601011 | AZ 12601011
-
PathwayTGF-beta/Smad
-
TargetTGFBR
-
RecptorTGFBR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight313.364
-
Molecular FormulaC19H15N5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Spender LC, et al. Mol Pharmacol. 2018 Nov 20. pii: mol.118.112946. doi: 10.1124/mol.118.112946.
molnova catalog
related products
-
LDN-214117
A potent and selective ALK2 inhibitor with a biochemical IC50 of 24 nM, a cell-based IC50 for BMP6 of 100 nM.
-
TASP0382088
A potent, selective ALK5 inhibitor with IC50 of 4.8 nM.
-
A 83-01
A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
