Cart
sales@molnova.com
TP-0427736
CAS No. 864374-00-5
TP-0427736( TP0427736 )
Catalog No. M16267 CAS No. 864374-00-5
TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 214 | Get Quote |
|
| 10MG | 350 | Get Quote |
|
| 25MG | 597 | Get Quote |
|
| 50MG | 851 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTP-0427736
-
NoteResearch use only, not for human use.
-
Brief DescriptionTP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
-
DescriptionTP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=8.7 nM) and decreases the growth inhibition of human outer root sheath cells; significantly decreases Smad2 phosphorylation in mouse skin after topical application, may serves as a potential new therapy for AGA.
-
In Vitro——
-
In Vivo——
-
SynonymsTP0427736
-
PathwayTGF-beta/Smad
-
TargetTGFBR
-
RecptorTGFBR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number864374-00-5
-
Formula Weight298.382
-
Molecular FormulaC14H10N4S2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)NC=N2)=N1
-
Chemical Name6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.
2. Naruse T, et al. Pharmacol Rep. 2017 Jun;69(3):485-491.
molnova catalog
related products
-
VU 0465350
A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
-
Pirfenidone
Pirfenidone is an inhibitor for?TGF-β?production and TGF-β stimulated collagen production.
-
LY2109761
A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively.
