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TP-0427736
CAS No. 864374-00-5
TP-0427736( TP0427736 )
Catalog No. M16267 CAS No. 864374-00-5
TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 214 | Get Quote |
|
| 10MG | 350 | Get Quote |
|
| 25MG | 597 | Get Quote |
|
| 50MG | 851 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTP-0427736
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NoteResearch use only, not for human use.
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Brief DescriptionTP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
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DescriptionTP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=8.7 nM) and decreases the growth inhibition of human outer root sheath cells; significantly decreases Smad2 phosphorylation in mouse skin after topical application, may serves as a potential new therapy for AGA.
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In Vitro——
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In Vivo——
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SynonymsTP0427736
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFBR
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Research Area——
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Indication——
Chemical Information
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CAS Number864374-00-5
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Formula Weight298.382
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Molecular FormulaC14H10N4S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)NC=N2)=N1
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Chemical Name6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.
2. Naruse T, et al. Pharmacol Rep. 2017 Jun;69(3):485-491.
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