GSK-6853
CAS No. 1910124-24-1
GSK-6853 ( GSK6853 )
Catalog No. M12992 CAS No. 1910124-24-1
A potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | In Stock |
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5MG | 53 | In Stock |
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10MG | 98 | In Stock |
|
25MG | 177 | In Stock |
|
50MG | 309 | In Stock |
|
100MG | 478 | In Stock |
|
500MG | 1035 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK-6853
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.
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DescriptionA potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1; displays>1600-fold selectivity over others bromodomains (BRPF2/3, BRD4 BD1/BD2); displaces NanoLuc-tagged BRPF1 bromodomain from Halo-tagged histone H3.3 (IC50=20 nM) and disrupts chromatin binding in cell assays; demonstrates properties suitable for cellular and in vivo studies.
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SynonymsGSK6853
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBRPF1;BRPF2;BRPF3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1910124-24-1
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Formula Weight409.48
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Molecular FormulaC22H27N5O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 29 mg/mL
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SMILESO=C(NC1=C(N2[C@H](C)CNCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
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Chemical NameBenzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bamborough P, et al. ACS Med Chem Lett. 2016 May 9;7(6):552-7.
molnova catalog
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