GSK-2807 ( GSK 2807;GSK2807 )

Catalog No. M13602 CAS No. 2245255-65-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK-2807
Note

Research use only, not for human use.
Brief Description

GSK-2807 (GSK 2807, GSK2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM.
Description

GSK-2807 (GSK 2807, GSK2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM; displays 24-fold selectivity over SMYD2, and a panel of PRMTs including: PRMT1, PRMT4, PRMT5, NSD2, NSD3, DOT1L, G9a, and ASH1L.
Synonyms

GSK 2807;GSK2807
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

2245255-65-4
Formula Weight

452.52
Molecular Formula

C19H32N8O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)[C@@H](N)CCN(C[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)CCCN(C)C
Chemical Name

(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(dimethylamino)propyl)amino)butanoic acid

1. Van Aller GS, et al. Structure. 2016 May 3;24(5):774-81.

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