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UNC0379

CAS No. 1620401-82-2

UNC0379 ( UNC 0379;UNC-0379 )

Catalog No. M12379 CAS No. 1620401-82-2

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UNC0379
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
  • Description
    UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM); causes neuroblastoma (NB) cell growth inhibition which is p53 dependent, reduces levels of p53K382me1 modification in xenografts.
  • Synonyms
    UNC 0379;UNC-0379
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    SETD8
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1620401-82-2
  • Formula Weight
    413.56
  • Molecular Formula
    C23H35N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    COC1=C(OC)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1
  • Chemical Name
    4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.
2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.
3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.
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