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UNC0379
CAS No. 1620401-82-2
UNC0379 ( UNC 0379;UNC-0379 )
Catalog No. M12379 CAS No. 1620401-82-2
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 131 | In Stock |
|
| 50MG | 222 | In Stock |
|
| 100MG | 335 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUNC0379
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NoteResearch use only, not for human use.
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Brief DescriptionUNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
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DescriptionUNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM); causes neuroblastoma (NB) cell growth inhibition which is p53 dependent, reduces levels of p53K382me1 modification in xenografts.
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SynonymsUNC 0379;UNC-0379
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorSETD8
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1620401-82-2
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Formula Weight413.56
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Molecular FormulaC23H35N5O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCOC1=C(OC)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1
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Chemical Name4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.
2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.
3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.
2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.
3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.
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