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GSK-229423
CAS No. 1352149-24-6
GSK-229423( GSK229423 )
Catalog No. M11427 CAS No. 1352149-24-6
GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK-229423
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
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DescriptionGSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM; displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101; has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.
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In Vitro——
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In Vivo——
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SynonymsGSK229423
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1352149-24-6
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Formula Weight459.612
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Molecular FormulaC26H29N5OS
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1=C(CCN2CCC(NCC3=CC4=C(OCS4)C=N3)CC2)C5=CC(OC)=CC=C5N=C1
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Chemical Name4-(2-(4-(([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-6-ethylquinoline-3-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.
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