GSK-229423 ( GSK229423 )

Catalog No. M11427 CAS No. 1352149-24-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK-229423
Note

Research use only, not for human use.
Brief Description

GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
Description

GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM; displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101; has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.
Synonyms

GSK229423
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1352149-24-6
Formula Weight

459.61
Molecular Formula

C26H29N5OS
Purity

>98% (HPLC)
Solubility

——
SMILES

N#CC1=C(CCN2CCC(NCC3=CC4=C(OCS4)C=N3)CC2)C5=CC(OC)=CC=C5N=C1
Chemical Name

4-(2-(4-(([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-6-ethylquinoline-3-carbonitrile

1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.

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