
GNE-9605
CAS No. 1536200-31-3
GNE-9605( GNE9605 | GNE 9605 )
Catalog No. M12169 CAS No. 1536200-31-3
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 49 | In Stock |
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5MG | 80 | In Stock |
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10MG | 147 | In Stock |
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25MG | 300 | In Stock |
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50MG | 444 | In Stock |
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100MG | 659 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameGNE-9605
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM.
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DescriptionGNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM; dispalys excellent selectivity against 178-membered Invitrogen kinase panel, as well as a representative panel of receptors and ion channels; demonstrates robust concentration-dependent inhibition of LRRK2 Ser1292 autophosphorylation (IC50=20 nM) in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation.
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In Vitro——
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In VivoGNE-9605 (10 and 50 mg/kg; i.p.; once) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein.GNE-9605 (1 mg/kg, p.o.; 0.5 mg/kg, i.v.; once) displays LRRK2 Ki in the biochemical assay of 2 nM as well as a cellular IC50 of 19 nM. GNE-9605 has a total plasma clearance with excellent oral bioavailability. Animal Model:BAC transgenic mice expressing human LRRK2 protein.Dosage:10 and 50 mg/kg Administration:Intraperitoneal injection; once Result:Inhibited LRRK2 Ser1292 autophosphorylation in a dose-dependent manner.Animal Model:BAC transgenic mice expressing human LRRK2 protein.Dosage:1 mg/kg, p.o.; 0.5 mg/kg, i.v.Administration:Oral administration and intravenous injection; once Result:Demonstrated a total plasma clearance of 26 mL min-1 kg-1 with excellent oral bioavailability (90%).
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SynonymsGNE9605 | GNE 9605
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PathwayAutophagy
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TargetLRRK2
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RecptorLRRK2
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1536200-31-3
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Formula Weight449.8336
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Molecular FormulaC17H20ClF4N7O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 60 mg/mL
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SMILESFC(C1=CN=C(NC2=C(Cl)N([C@H]3[C@H](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
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Chemical Name2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Estrada AA, et al. J Med Chem. 2014 Feb 13;57(3):921-36.
molnova catalog



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