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SR 9444
CAS No. 1442659-77-9
SR 9444( SR9444 )
Catalog No. M11876 CAS No. 1442659-77-9
SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSR 9444
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NoteResearch use only, not for human use.
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Brief DescriptionSR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.
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DescriptionSR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively; shows reasonable selectivity against a panel of 116 kinases; exhibits good cell potency, inhibits LRRK2:G2019S-induced mitochondrial dysfunction in SHSY5Y cells.
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In Vitro——
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In Vivo——
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SynonymsSR9444
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PathwayAutophagy
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TargetLRRK2
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RecptorLRRK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1442659-77-9
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Formula Weight696.849
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Molecular FormulaC39H48N6O6
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(2-((2-((6-(4-(1H-indazol-3-yl)benzamido)hexyl)amino)-2-oxoethyl)(isobutyl)amino)-2-oxoethyl)-6-methoxychromane-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Feng Y, et al. ACS Chem Biol. 2013 Aug 16;8(8):1747-54.
molnova catalog
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MLi-2
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JH-II-127
A potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively.
