Cart
sales@molnova.com
SR 9444
CAS No. 1442659-77-9
SR 9444( SR9444 )
Catalog No. M11876 CAS No. 1442659-77-9
SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSR 9444
-
NoteResearch use only, not for human use.
-
Brief DescriptionSR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.
-
DescriptionSR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively; shows reasonable selectivity against a panel of 116 kinases; exhibits good cell potency, inhibits LRRK2:G2019S-induced mitochondrial dysfunction in SHSY5Y cells.
-
In Vitro——
-
In Vivo——
-
SynonymsSR9444
-
PathwayAutophagy
-
TargetLRRK2
-
RecptorLRRK2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1442659-77-9
-
Formula Weight696.849
-
Molecular FormulaC39H48N6O6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameN-(2-((2-((6-(4-(1H-indazol-3-yl)benzamido)hexyl)amino)-2-oxoethyl)(isobutyl)amino)-2-oxoethyl)-6-methoxychromane-3-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Feng Y, et al. ACS Chem Biol. 2013 Aug 16;8(8):1747-54.
molnova catalog
related products
-
PFE-360
PFE-360 is a novel potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.
-
LRRK2-IN-1
A potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay).
-
GNE-9605
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM.
