GNE-886
CAS No. 2101957-05-3
GNE-886 ( GNE886 )
Catalog No. M13340 CAS No. 2101957-05-3
GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGNE-886
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains.
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DescriptionGNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.
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SynonymsGNE886
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number2101957-05-3
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Formula Weight498.59
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Molecular FormulaC28H30N6O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCN(C1CCN(CC1)C2=NC=NC(=C2)C3=CC(=CC=C3)OC)C(=O)C4=CN(C(=O)C5=C4C=CN5)CC=C
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Chemical Name6-allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741.
molnova catalog
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